The South Node in the twelfth house shows accumulated experience of solitude, spiritual searching, closed spaces, the unconscious, distant journeys, sleep, hidden expenses, subtle sciences and withdrawal from ordinary life. Sources on Ketu in the twelfth house mention interest in spirituality, psychology and sciences of the spirit, ability to understand subtleties, but also insomnia, eye or ear problems, unexpected expenses, debts, inability to accept good advice and life in isolation.
This placement may give subtle perception. The person senses hidden states, can go inward, understand dreams, symbols, psychological depths, spiritual practices, art and the pain of loneliness. For a mature person this is a strong resource of compassion and inner wisdom. But familiar withdrawal into the invisible may become avoidance of life.
